The Redeemability Scale

Can a non-villain main character go too far and become unredeemable? Where is the line, and why is it drinking decaf? The transgressions are:
Quirks, Small Vices, Lying, Violence, Infidelity, Misdemeanors, Betrayal, Torture, Murder, Mind Control, Hurting Animals, Genocide, Sexism and Misogyny, Bigotry, Slavery, and others.